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Updated: Jun 16, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

The Gene-Environment Interactions in Respiratory Diseases (GEIRD) Project.

R de Marco¹, S Accordini, L Antonicelli

¹University of Verona, Italy. roberto.demarco@univr.it

International Archives of Allergy and Immunology

|February 13, 2010

Summary

Investigating genetic and environmental factors in asthma, allergic rhinitis, and COPD is crucial. The GEIRD project aims to build a large database to understand these inflammatory airway diseases better.

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Area of Science:

Epidemiology
Genetics
Environmental Health

Background:

The interplay of genetic and environmental factors in asthma, allergic rhinitis, and COPD pathogenesis remains largely uncharacterized.
A significant gap exists in large-scale epidemiological and genetic studies investigating these three major respiratory conditions concurrently.

Purpose of the Study:

To elucidate the roles of modifiable and genetic factors in the development, persistence, severity, and management of inflammatory airway diseases.
To establish a historical, multicenter, standardized databank of respiratory phenotypes for international epidemiological research.
To facilitate a deeper understanding of the natural history of asthma, allergic rhinitis, and COPD.

Main Methods:

The GEIRD project employs a population-based, multicase-control design.
A two-stage screening process (postal questionnaire and clinical examination) identifies cases and controls from existing cohorts and new samples.
Data collection focuses on biomarkers of inflammation and oxidative stress, exposures (individual and ecological), diet, early-life factors, smoking, genetics, and medication use.

Main Results:

The project is establishing a comprehensive, standardized databank of respiratory phenotypes.
It aims to increase statistical power for epidemiological research on inflammatory airway diseases.
The initiative will provide a valuable resource for researchers investigating the etiology of asthma, allergic rhinitis, and COPD.

Conclusions:

The GEIRD project will significantly advance the understanding of genetic and environmental influences on major respiratory diseases.
The creation of an open-access databank will foster collaborative research and accelerate discoveries in respiratory medicine.
This initiative addresses the critical need for large-scale, simultaneous investigation of asthma, allergic rhinitis, and COPD.