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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
08:43

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

'Image and treat': an individualized approach to urological tumors

Kirsten Bouchelouche1, Jacek Capala

  • 1PET and Cyclotron Unit, PET 3982 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. bouchelouche@mail.tele.dk

Current Opinion in Oncology
|February 13, 2010
PubMed
Abstract

Insights

Personalized nuclear medicine, combining molecular imaging and targeted radionuclide therapy, offers new hope for advanced urologic cancers. This

Area of Science:

  • Uro-oncology
  • Nuclear Medicine
  • Personalized Medicine

Background:

  • Current treatments for advanced urologic cancers have limited efficacy.
  • Individualized therapeutic strategies are emerging for these malignancies.
  • Nuclear medicine provides essential imaging biomarkers for personalized medicine.

Purpose of the Study:

  • To review the 'image and treat' approach for urological malignancies.
  • Focus on combining molecular imaging with targeted radionuclide therapy.
  • Highlight the role of nuclear medicine in personalized urologic oncology.

Main Methods:

  • Review of current literature on molecular imaging and radionuclide therapy in urologic cancers.
  • Evaluation of tumor-specific targets for imaging and therapy.
  • Analysis of positron emission tomography/computed tomography (PET/CT) applications.

Main Results:

  • Tumor-specific targets like carbonic anhydrase IX (cG250) and prostate-specific membrane antigen (PSMA) show promise.
  • Radioiodinated cG250 (I-cG250) PET/CT demonstrates effective targeting in clear-cell renal cell carcinoma.
  • PSMA is a viable target for PET/CT and radioimmunotherapy in prostate cancer; HER2 is a potential target for bladder and prostate cancer.

Conclusions:

  • Tumor-specific targets and biomarkers are under investigation for advanced PET/CT and radioimmunotherapy applications.
  • Development of novel therapeutic strategies is anticipated.
  • Significant research investment is necessary for routine clinical implementation of personalized medicine in uro-oncology.

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