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Circulating markers of arterial thrombosis and late-stage age-related macular degeneration: a case-control study

A R Rudnicka1, P K MacCallum, R Whitelocke

  • 1Division of Community Health Sciences, St George's, University of London, and Ophthalmology Department, Barts and The London NHS Trust, St Bartholomew's Hospital, Cranmer Terrace, London, UK. arudnicka@sgul.ac.uk

Eye (London, England)
|February 13, 2010
PubMed

Insights

This study found weak evidence linking atherothrombosis markers to age-related macular degeneration (AMD). Factor VIIc and prothrombin fragment F1.2 showed potential inverse associations with AMD risk.

Area of Science:

  • Ophthalmology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Age-related macular degeneration (AMD) is a leading cause of vision loss.
  • Atherothrombosis, characterized by clot formation in arteries, shares risk factors with cardiovascular disease.

Purpose of the Study:

  • To investigate the relationship between markers of systemic atherothrombosis and late-stage age-related macular degeneration (AMD).

Main Methods:

  • A hospital-based case-control study involving 81 AMD cases and 77 controls in London, UK.
  • Blood samples were analyzed for atherothrombotic markers including fibrinogen, factor VIIc (FVIIc), and prothrombin fragment F1.2 (F1.2).
  • Logistic regression analyses adjusted for cardiovascular risk factors like smoking, BMI, and cholesterol.

Main Results:

  • Factor VIIc (FVIIc) and potentially prothrombin fragment F1.2 (F1.2) showed an inverse association with AMD risk.
  • Increased FVIIc was linked to a 38% reduced odds of AMD (OR 0.62), and F1.2 to a 29% reduced odds (OR 0.71).
  • No significant associations were found for other atherothrombotic markers; weak evidence suggested aspirin may lower AMD risk.

Conclusions:

  • The study did not establish strong links between systemic arterial thrombosis markers and AMD.
  • The potential inverse associations of FVIIc and F1.2 with AMD warrant further investigation.
  • Further research is needed to clarify the complex interplay between atherothrombosis and AMD pathogenesis.
Abstract

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