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Updated: Jun 16, 2026
Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
Published on: February 5, 2011
Animal models of focal brain ischemia
Kenneth M Sicard1, Marc Fisher
1Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01453, USA. sicardk@ummhc.org
Abstract:
Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology of ischemic injury and developing therapies is an important endeavor that requires much additional research. Animal stroke models provide an important mechanism for these activities. A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome.
