Related Experiment Video

Updated: Jun 16, 2026

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
08:53

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Risk factors in community-acquired urinary tract infections caused by ESBL-producing bacteria in children

Rezan Topaloglu1, Ilkay Er, Bahar Guciz Dogan

  • 1Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey. rtopalog@hacettepe.edu.tr

Pediatric Nephrology (Berlin, Germany)
|February 13, 2010
PubMed

Insights

Children with underlying diseases or recent hospitalizations face higher risks of community-acquired urinary tract infections (UTI) caused by extended-spectrum beta-lactamases (ESBL)-producing bacteria.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Community-acquired urinary tract infections (UTI) are common in children.
  • Extended-spectrum beta-lactamases (ESBL)-producing bacteria are a growing concern in pediatric UTIs.
  • Identifying risk factors for ESBL-positive UTI is crucial for effective management.

Purpose of the Study:

  • To investigate risk factors associated with community-acquired UTI in children caused by ESBL-producing E. coli or Klebsiella spp.
  • To identify independent risk factors for ESBL-positive UTI in pediatric patients.

Main Methods:

  • Retrospective analysis of 310 pediatric patients diagnosed with UTI between January 2004 and December 2006.
  • Comparison of a case group with ESBL-positive UTI (n=155) and a control group with ESBL-negative UTI (n=155), matched for age and sex.
  • Conditional logistic regression analysis to determine independent risk factors.

Main Results:

  • No significant difference in UTI symptoms between ESBL-positive and ESBL-negative groups.
  • Klebsiella spp. was more frequent in the ESBL-positive UTI group compared to the ESBL-negative group.
  • Underlying disease, recent hospitalization, infections, and antibiotic use within 3 months were potential risk factors. Underlying disease and recent hospitalization were identified as independent risk factors.

Conclusions:

  • Underlying diseases and recent hospitalizations are significant independent risk factors for ESBL-positive UTI in children.
  • Early recognition of these risk factors can aid in identifying high-risk pediatric cases.
  • This knowledge supports improved management strategies for pediatric ESBL-positive UTIs.

More Related Videos

Establishment and Characterization of UTI and CAUTI in a Mouse Model08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Related Concept Videos

Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Urinary Tract Infection I: Introduction01:26

Urinary Tract Infection I: Introduction

Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...