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Expression of Epiplakin1 in the developing and adult mouse retina
Tetsu Yoshida1, Xiaoli Guo, Kazuhiko Namekata
1Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan.
Purpose:
To assess the expression of Epiplakin1 (Eppk1) in the developing and adult mouse retina.
Methods:
Eppk1 expression was examined using reverse transcription-polymerase chain reaction (RTPCR) analysis and immunoblot analysis. The Eppk1 expression pattern was examined by immunohistochemical analysis in embryonic and adult C57BL/6J mice.
Results:
Both Eppk1 mRNA and protein were detected in adult mouse retina. Eppk1 was expressed in nestin-positive neural progenitor cells in the embryonic retina. In adults, Eppk1 was expressed in retinal ganglion cells, bipolar cells, and Müller glial cells.
Conclusions:
These results suggest that Eppk1 is expressed both in embryonic and adult retina and may be involved in retinal development.
