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Updated: Jun 16, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
The resurgence of acyclic nucleic acids
Su Zhang1, Christopher Switzer, John C Chaput
1Center for Evolutionary Functional Genomics, The Biodesign Institute, and Department of Chemistry and Biochemistry at Arizona State University, Tempe, Arizona 85287-5301, USA.
Abstract:
This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic-acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self-assembly.
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