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Related Experiment Video

Updated: Jun 16, 2026

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

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Published on: March 8, 2024

Differential gene expression in migrating cortical interneurons during mouse forebrain development.

Clare Faux¹, Sonja Rakic, William Andrews

¹Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom.

The Journal of Comparative Neurology

|February 13, 2010

Summary

Researchers identified novel genes crucial for gamma-aminobutyric acid (GABA)ergic interneuron migration into the cerebral cortex. Understanding these genes may offer insights into neurological disorders like epilepsy and schizophrenia.

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Last Updated: Jun 16, 2026

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

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Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

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Published on: April 20, 2018

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Area of Science:

Neuroscience
Developmental Biology
Genetics

Background:

Gamma-aminobutyric acid (GABA)ergic interneurons are essential for cerebral cortex function.
Disruptions in GABAergic interneuron migration are implicated in neurological disorders such as schizophrenia and epilepsy.
The signaling mechanisms governing interneuron migration remain largely unknown.

Purpose of the Study:

To identify novel genes regulating the migration of GABAergic interneurons from the ganglionic eminences (GE) to the cortex.
To compare gene expression profiles between migrating cortical interneurons and those within the GE.

Main Methods:

Microarray analysis of purified GABAergic interneurons from GAD67-GFP transgenic mice.
Fluorescence-activated cell sorting (FACS) to isolate pure interneuron populations.
Quantitative polymerase chain reaction (qPCR) and in situ hybridization for gene validation.

Main Results:

Identified several novel genes upregulated in migrating cortical interneurons at E13.5 and E15.5.
Many identified genes are known to be involved in cell migration, neurite outgrowth, cell adhesion, and cytoskeletal remodeling.
Confirmed restricted expression of some novel genes to cortical interneurons.

Conclusions:

The study provides a framework for understanding the molecular mechanisms of interneuron migration.
Identified genes offer potential targets for future research into neurological disorders linked to interneuron dysfunction.
This research sheds light on the genetic basis of cortical development and associated pathologies.