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Updated: Jun 16, 2026

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy
Published on: March 29, 2020
Association between naturally occurring chronic kidney disease and feline immunodeficiency virus infection status in
Joanna D White1, Richard Malik, Jacqueline M Norris
1Faculty of Veterinary Science, University of Sydney, NSW, Australia. J.White@massey.ac.nz
Objective:
To investigate the association between naturally occurring chronic kidney disease (CKD) and FIV infection status in cats in Australia.
Design:
Case-control study.
Animals:
73 cats with CKD and 69 cats without historical, physical, or clinicopathologic evidence of CKD.
Procedures:
Cats were tested for serum antibodies against FIV glycoprotein 40 (gp40) by use of an immunomigration assay. Information regarding age, breed (purebred or domestic), and sex was obtained from medical records. Analysis was performed on data from cats stratified into 2 age categories (< 11 years old and >or= 11 years old). Univariable and then multivariable analyses were performed to investigate the relationship between CKD and the study variable (FIV infection), the latter analysis accounting for breed (purebred or domestic), sex, and veterinary hospital of origin.
Results:
Results of multivariable analysis revealed that younger cats with CKD (< 11 years old) were significantly more likely to have positive test results for serum antibodies against FIV gp40 than were cats without CKD. No significant associations were found between CKD and FIV infection, breed, sex, or hospital of origin among older (>or= 11 years old) cats in the multivariable analysis.
Conclusions And Clinical Relevance:
Among cats < 11 years of age, those with CKD were significantly more likely to have positive test results for serum antibodies against FIV gp40 than were cats without CKD. It cannot be definitively established from results of this study whether infection with FIV preceded the development of CKD, and the role, if any, of FIV in the establishment or progression of CKD remains to be determined.
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