Related Experiment Video
Updated: Jun 16, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
Published on: March 11, 2020
Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease
Michael S Levine1, Carlos Cepeda, Véronique M André
1Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095, USA. mlevine@mednet.ucla.edu
Abstract:
Abnormally enhanced N-methyl-D-aspartate (NMDA) receptor function is implicated in Huntington's disease (HD). In this issue of Neuron and a recent issue of Nature Medicine, an abnormal balance between the activity of NMDA receptors at synaptic (prosurvival) and extrasynaptic (proapoptotic) sites has been uncovered in a cellular and a mouse model of HD.
Related Concept Videos
Huntington Disease l: Introduction
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Long-term Depression
Ligand-Gated Ion Channel Receptor: Gating Mechanism

