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A new dress code for MMPs: cleavage optional
Barbara Fingleton1, Conor C Lynch
1Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
Abstract:
Matrix metalloproteinases are well known for their key roles in the processing of extracellular matrix and nonmatrix molecules. Recently, a new theme of proteolysis-independent roles for metalloproteinases has emerged, with a paper from Gonzalo et al. in this issue of Developmental Cell providing an illustration.
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M-Cdk Drives Transition Into Mitosis
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...

