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Related Experiment Video

Updated: Jun 16, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Renal sympathetic denervation and systemic hypertension.

Michael Doumas¹, Charles Faselis, Vasilios Papademetriou

¹Veterans Affairs Medical Center and George Washington University, Washington, District of Columbia, USA.

The American Journal of Cardiology

|February 16, 2010

Summary

Resistant hypertension may be treated with renal sympathetic denervation (RSD), a minimally invasive procedure. This catheter-based radiofrequency ablation offers a new interventional strategy for managing difficult-to-treat high blood pressure.

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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Area of Science:

Cardiovascular Medicine
Interventional Cardiology
Nephrology

Background:

Hypertension is a significant global health issue with high mortality.
Resistant hypertension affects numerous patients despite available drug therapies, necessitating novel treatment strategies.
Renal sympathetic denervation (RSD) has emerged as a promising interventional approach.

Purpose of the Study:

To review the pathophysiologic basis for using RSD in hypertension management.
To discuss the historical context and current status of RSD as an interventional therapy.
To explore potential future applications of RSD.

Main Methods:

Percutaneous, catheter-based radiofrequency ablation targeting renal sympathetic nerves.
Review of existing data on sympathectomy and modern RSD techniques.
Analysis of the pathophysiology linking kidney function and sympathetic nervous system activity.

Main Results:

Older sympathectomy procedures lowered blood pressure but had significant costs and side effects.
Modern RSD is minimally invasive, localized, and associated with shorter procedural and recovery times.
RSD has demonstrated benefits in patients with resistant hypertension.

Conclusions:

The pathophysiology of kidney function supports RSD for hypertension treatment.
RSD offers a safer, less invasive alternative to traditional sympathectomy.
RSD represents a significant advancement in interventional strategies for resistant hypertension.