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Updated: Jun 16, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
Multiple synchronous tumors in a child with Fanconi anemia
Alessia Compostella1, Tiziana Toffolutti, Pietro Soloni
1Hematology/Oncology Division, Department of Pediatrics, University Hospital of Padova, 35128 Padova, Italy.
Abstract:
Fanconi anemia (FA) is an autosomal recessive inherited syndrome characterized by congenital abnormalities, aplastic anemia, and a high likelihood of developing cancer. We describe a child who presented with 2 synchronous solid tumors (Wilms tumor and neuroblastoma), later found to have FA, who developed severe toxicity and died after a first cycle of chemotherapy. Our experience emphasizes that a predisposing genetic condition should be sought in cases of multiple tumors and that managing FA patients with cancer can be particularly difficult.
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