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Updated: Jun 16, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Enhanced effect of double-stacked intrastromal corneal ring segments in keratoconus
1Duke Eye Center, Durham, North Carolina, USA. drfeldman@phillyeye.com
Abstract:
We present a patient with poor visual acuity and contact lens intolerance due to advanced keratoconus who had femtosecond-assisted placement of two 0.35 mm intrastromal corneal ring segments (ICRS) in the right eye. Postoperatively, both rings migrated inferiorly and overlapped each other in a double-stacked formation. This resulted in a dramatic central shift of the cone and flattening of the inferior paracentral cornea with significant improvement in vision. To our knowledge, this is the first report of double-stacked ICRS in a human cornea and raises the possibility that significantly thicker segments may provide enhanced anatomic and visual effects in some keratoectatic patients.
