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Related Experiment Video

Updated: Jun 16, 2026

Determination of Photoreceptor Cell Spectral Sensitivity in an Insect Model from In Vivo Intracellular Recordings

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Published on: February 26, 2016

Synophrys.

Matthias Möhrenschlager¹, Martin Lauenstein, Johannes Ring

¹Department of Dermatology and Allergology, Allergieklinik, Davos, Switzerland. Matthias.Moehrenschlager@hgk.ch

European Journal of Medical Genetics

|February 16, 2010

Summary

This summary is machine-generated.

Synophrys, or a unibrow, can indicate syndromal disorders but is not always a definitive sign. This case highlights a man with a unibrow and other symptoms, yet no underlying syndrome.

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Area of Science:

Dermatology
Clinical Genetics

Background:

Synophrys (medial eyebrow meeting) is a potential cutaneous marker for syndromal disorders like Cornelia de Lange syndrome.
Understanding the diagnostic significance of synophrys is crucial in clinical practice.

Observation:

A 31-year-old male presented with synophrys, forming a single band of terminal hair across the brow.
The patient exhibited cold-inducible urticaria, xanthelasma, and long eyelashes.

Findings:

Despite the presence of synophrys and other dermatological findings, the patient showed no clinical signs of a syndromal disorder.
This case underscores that synophrys is not pathognomonic for any specific illness.

Implications:

Synophrys alone is insufficient for diagnosing syndromal disorders.
Further investigation is warranted when synophrys presents with other clinical features to rule out or confirm underlying conditions.