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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Association between peanut allergy and asthma morbidity.

Alyson B Simpson¹, Ejaz Yousef, Jobayer Hossain

¹Department of Pediatrics, Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.

The Journal of Pediatrics

|February 16, 2010

Summary

Peanut allergy is linked to increased asthma problems in children. Early detection and treatment of peanut allergy may reduce asthma-related hospitalizations and steroid use.

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Last Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Area of Science:

Pediatric Allergy and Immunology
Respiratory Medicine
Clinical Epidemiology

Background:

Asthma is a common chronic respiratory disease in children.
Peanut allergy is a prevalent food allergy with potential systemic implications.
The relationship between peanut allergy and asthma morbidity requires further elucidation.

Purpose of the Study:

To investigate the association between peanut allergy and asthma morbidity in school-aged children.
To determine if peanut allergy predicts increased asthma exacerbations.

Main Methods:

Retrospective medical chart review of children over 3 years of age.
Peanut allergy diagnosis confirmed by validated criteria.
Poisson regression analysis to compare asthma hospitalization and systemic steroid use rates.

Main Results:

Children with peanut allergy exhibited a 2.32-fold increased rate of asthma hospitalization (P = .03).
Peanut-allergic children had a 1.59-fold higher rate of systemic steroid use (P <.001).
These associations remained significant after controlling for confounding variables.

Conclusions:

Peanut allergy is identified as an early indicator of significant asthma morbidity.
Proactive management strategies for peanut allergy could potentially mitigate asthma-related health issues.
Early intervention in peanut-allergic children may enhance overall care quality and outcomes.