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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Overall asthma control: the relationship between current control and future risk.

Eric D Bateman1, Helen K Reddel, Göran Eriksson

  • 1Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa. Eric.Bateman@uct.ac.za

The Journal of Allergy and Clinical Immunology
|February 16, 2010
PubMed
Summary
This summary is machine-generated.

Maintaining asthma control is key to reducing future exacerbations. Budesonide/formoterol maintenance and reliever therapy effectively lowers exacerbation risk and achieves good asthma control.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Clinical Medicine

Background:

  • Asthma management guidelines highlight dual goals: maintaining current symptom control and mitigating future exacerbation risk.
  • The interplay between achieving current asthma control and reducing future risk remains incompletely understood.

Purpose of the Study:

  • To analyze the relationship between asthma control (using Asthma Control Questionnaire-5) and clinical control (Global Initiative for Asthma criteria).
  • To assess the impact of budesonide/formoterol maintenance and reliever therapy on future asthma instability and exacerbation risk.
  • To compare budesonide/formoterol maintenance and reliever therapy with other controller regimens.

Main Methods:

  • Retrospective analysis of five clinical studies involving budesonide/formoterol maintenance and reliever therapy.
  • Evaluation of the proportion of patients achieving Global Initiative for Asthma-defined controlled asthma over time across different treatment groups.
  • Investigation of the correlation between baseline Asthma Control Questionnaire-5 scores and subsequent exacerbation rates, utilizing Markov analysis for control status transitions.

Main Results:

  • Asthma control improved over time across all treatments; budesonide/formoterol maintenance and reliever therapy showed comparable or superior control rates versus higher-dose ICS, same-dose ICS/LABA, and higher-dose ICS/LABA.
  • A positive correlation was observed between baseline Asthma Control Questionnaire-5 scores and exacerbation frequency.
  • Achieving controlled or partly controlled asthma in one week predicted at least partly controlled asthma in the subsequent week with high probability (>80%).
  • Improved current asthma control correlated with a reduced risk of future uncontrolled asthma and exacerbations, particularly with budesonide/formoterol maintenance and reliever therapy.

Conclusions:

  • Current asthma control status is a significant predictor of future asthma instability and exacerbation risk.
  • Budesonide/formoterol maintenance and reliever therapy demonstrated a reduction in exacerbations compared to alternative maintenance therapies.
  • The budesonide/formoterol maintenance and reliever therapy regimen achieved asthma control outcomes that were at least similar to comparator treatments.