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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...

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Related Experiment Video

Updated: Jun 16, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

[High volume hemofiltration in septic shock].

C M Romero1, P Downey, G Hernández

  • 1Departamento de Medicina, Facultad de Medicina, Universidad de Chile, Santiago, Chile. caromero@redclinicauchile.cl

Medicina Intensiva
|February 16, 2010
PubMed
Summary
This summary is machine-generated.

Severe sepsis and septic shock increase mortality. High volume hemofiltration, a "septic dose," may improve cardiovascular stability by removing inflammatory mediators, unlike standard renal replacement therapy.

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Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
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Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

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Last Updated: Jun 16, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Immunology

Context:

  • Severe sepsis and septic shock are life-threatening conditions with high mortality rates.
  • Sepsis triggers a dysregulated inflammatory response, leading to multiple organ dysfunction.
  • Conventional renal replacement therapies (hemodialysis, hemofiltration) primarily remove small molecules, failing to clear inflammatory mediators.

Purpose:

  • To review the clinical and pathophysiological rationale for using high volume hemofiltration in septic shock.
  • To evaluate the efficacy of a higher ultrafiltration rate ('septic dose') beyond standard renal replacement therapy.
  • To explore the potential of high volume hemofiltration in stabilizing cardiovascular function during septic shock.

Summary:

  • Severe sepsis and septic shock are characterized by excessive inflammatory mediator release, contributing to organ dysfunction.
  • Standard renal replacement therapy effectively clears small molecules but is insufficient for removing medium-sized inflammatory mediators.
  • High volume hemofiltration, defined as ultrafiltration > 50 ml/kg/h, is proposed as a 'septic dose' to address mediator clearance and cardiovascular stabilization.

Impact:

  • High volume hemofiltration may offer a therapeutic strategy to improve outcomes in septic shock patients.
  • This approach targets the removal of key inflammatory mediators implicated in sepsis pathophysiology.
  • Understanding the 'septic dose' rationale can guide clinical practice in managing critically ill septic patients.