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Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
Published on: May 17, 2019
[Extracorporeal photochemotherapy or immunotherapy using cells modified by photochemistry]
D Hannani1, F Gabert, L Chaperot
1Université Joseph-Fourier, Grenoble, France. joel.plumas@wanadoo.fr
La Revue De Medecine Interne
|February 16, 2010
Summary
Extracorporeal photochemotherapy (ECP) is an autologous cell therapy that uses UV-A radiation to treat diseases like lymphoma and organ rejection. ECP modulates the immune system to target pathogenic cells, potentially reducing the need for immunosuppressive drugs.
Area of Science:
- Immunology
- Photochemistry
- Cell Therapy
Context:
- Extracorporeal photochemotherapy (ECP) is an autologous cell therapy employed for treating diseases characterized by pathogenic cells.
- Conditions treated include cutaneous T-cell lymphoma, organ rejection, and graft versus host disease.
Purpose:
- To induce a specific immune reaction that modulates the activity of pathogenic lymphocytes.
- To improve clinical manifestations of the targeted diseases.
Summary:
- ECP involves treating a patient's autologous mononuclear cells with a photosensitizing agent and UV-A radiation.
- The modified cells are then reintroduced to the patient, aiming to elicit an immune response against disease-causing lymphocytes.
- The precise mechanisms of action in humans require further definition.
Impact:
- ECP demonstrates efficacy with a favorable side effect profile.
- It holds the potential to decrease the reliance on traditional immunosuppressive drugs.
- ECP represents an immunotherapy approach utilizing photochemically modified cells for targeted immune modulation.
