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Updated: Jun 16, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
Published on: March 8, 2018
Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder
Anthony C Ruocco1, John D Medaglia, Jennifer R Tinker
1Department of Psychology, Drexel University, Philadelphia, PA, United States. anthony.ruocco@gmail.com
Abstract:
Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n=10) and matched non-psychiatric comparison subjects (n=10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.
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