Signal transduction to the permeability transition pore
Related Experiment Video
Updated: Jun 16, 2026

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Published on: June 1, 2022
Andrea Rasola1, Marco Sciacovelli, Boris Pantic
1Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy. rasola@bio.unipd.it
Abstract:
The permeability transition pore (PTP) is an inner mitochondrial membrane channel that has been thoroughly characterized functionally, yet remains an elusive molecular entity. The best characterized PTP-regulatory component, cyclophilin (CyP) D, is a matrix protein that favors pore opening. CyP inhibitors, CyP-D null animals, and in situ PTP readouts have established the role of PTP as an effector mechanism of cell death, and the growing definition of PTP signalling mechanisms. This review briefly covers the functional features of the PTP and the role played by its dysregulation in disease pathogenesis. Recent progress on PTP modulation by kinase/phosphatase signal transduction is discussed, with specific emphasis on hexokinase and on the Akt-ERK-GSK3 axis, which might modulate the PTP through CyP-D phosphorylation.
More Related Videos
11:55Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
13:40Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca2+ Leak Channels in the ER Membrane and their Regulatory Mechanisms
Published on: July 7, 2011
Related Concept Videos
G-Protein Gated Ion Channels
Sensory organs,...
Amplifying Signals via Second Messengers
IP3/DAG Signaling Pathway
Signal Transduction: Overview
Typically, signal transduction involves three...
What are Second Messengers?
Cell-surface Signaling