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Updated: Jun 16, 2026

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Published on: June 1, 2022
Signal transduction to the permeability transition pore
Andrea Rasola1, Marco Sciacovelli, Boris Pantic
1Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy. rasola@bio.unipd.it
The mitochondrial permeability transition pore (PTP) is crucial in cell death. Its regulation by cyclophilin D and kinase signaling pathways is key to understanding PTP
Area of Science:
- Mitochondrial biology
- Cell death mechanisms
- Biochemistry
Background:
- The permeability transition pore (PTP) is a critical inner mitochondrial membrane channel.
- Cyclophilin (CyP) D is a key regulator favoring PTP opening.
- PTP dysregulation is implicated in various disease pathologies.
Purpose of the Study:
- To review the functional characteristics of the PTP.
- To discuss the role of PTP dysregulation in disease.
- To highlight recent advances in PTP modulation by kinase/phosphatase signaling.
Main Methods:
- Functional characterization of PTP.
- Use of CyP inhibitors and CyP-D null animal models.
- In situ PTP readouts and signaling pathway analysis.
Main Results:
- Established PTP as an effector mechanism in cell death.
- Identified PTP signaling mechanisms.
- Highlighted modulation of PTP by kinase/phosphatase signaling, including hexokinase and the Akt-ERK-GSK3 axis.
Conclusions:
- The PTP is a vital component of cell death pathways.
- Kinase/phosphatase signaling, particularly involving CyP-D phosphorylation, represents a significant regulatory mechanism for PTP.
- Understanding these pathways offers therapeutic potential for diseases involving PTP dysregulation.
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