Body fat distribution and C-reactive protein--a principal component analysis
A Oliveira1, C Lopes, M Severo
1Department of Hygiene and Epidemiology and Cardiovascular Research & Development Unit, University of Porto Medical School, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. acmatos@med.up.pt
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|February 16, 2010
Summary
Central body fat is linked to higher inflammation (hs-CRP) in men. Peripheral fat is associated with lower inflammation in women. This study explores fat distribution and inflammation markers.
Area of Science:
- Human Physiology
- Biochemistry
- Public Health
Background:
- High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation.
- Body fat distribution, including general, central, and peripheral subcutaneous fat, may influence inflammation.
- Understanding these associations is crucial for public health and disease prevention.
Purpose of the Study:
- To investigate the independent associations between different types of body fat and hs-CRP levels.
- To differentiate the roles of general, central, and peripheral fat in inflammation.
- To analyze these relationships in both men and women from the general population.
Main Methods:
- Principal component analysis was used to identify independent anthropometric factors.
- Generalized linear models were employed to assess associations with hs-CRP.
- Data included anthropometric measurements and hs-CRP levels from a population sample in Porto, Portugal.
Main Results:
- Generalized fat distribution (high BMI and WC) showed a direct association with hs-CRP in both sexes.
- A central fat distribution pattern (high WC, high WHR, low BMI) was directly associated with hs-CRP in men.
- A high proportion of peripheral subcutaneous fat (PSFA) was inversely associated with hs-CRP in women.
Conclusions:
- Central fat distribution is linked to increased inflammation in men.
- Peripheral subcutaneous fat may have an anti-inflammatory role in women.
- Different fat depots have distinct associations with hs-CRP, varying by sex.
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