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Updated: Jun 16, 2026
07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Common predisposition alleles for moderately common cancers: bladder cancer
1Gray Institute for Radiation Oncology and Biology, Old Road Campus Research Building, Headington, Oxford, United Kingdom. anne.kiltie@rob.ox.ac.uk
Current Opinion in Genetics & Development
|February 16, 2010
Summary
Genetic factors contribute to bladder cancer risk. Recent genome-wide studies identified three significant single nucleotide polymorphisms (SNPs) near genes like MYC, TP63, and PSCA, suggesting a genetic predisposition.
Area of Science:
- Oncology
- Genetics
- Cancer Epidemiology
Background:
- Bladder cancer is a significant global health concern, ranking as the fifth most common cancer worldwide.
- Established risk factors include smoking and occupational chemical exposure, with growing evidence for a genetic component.
- Previous research focused on candidate genes involved in DNA adduct metabolism and repair.
Purpose of the Study:
- To investigate the genetic underpinnings of bladder cancer susceptibility.
- To identify novel genetic variants associated with bladder cancer risk through genome-wide association studies (GWAS).
Main Methods:
- Analysis of genome-wide association studies (GWAS) in bladder cancer.
- Identification and validation of single nucleotide polymorphisms (SNPs) with genome-wide significance.
Main Results:
- Two large-scale GWAS identified three SNPs associated with bladder cancer at genome-wide significance.
- Two of these significant SNPs are located in the 8q24 'gene desert' region.
- These SNPs are proximal to or within genes such as MYC, TP63, and PSCA, which are potentially involved in cancer predisposition.
Conclusions:
- Genome-wide association studies have revealed novel genetic loci associated with bladder cancer.
- The identified SNPs near MYC, TP63, and PSCA warrant further investigation to elucidate their functional role in bladder cancer etiology.
- These findings contribute to understanding the genetic architecture of bladder cancer risk.
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