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Vitamin E and age-related macular degeneration in a randomized trial of women
William G Christen1, Robert J Glynn, Emily Y Chew
1Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. wchristen@rics.bwh.harvard.edu
Objective:
To test whether alternate day vitamin E affects the incidence of age-related macular degeneration (AMD) in a large-scale randomized trial of women.
Design:
Randomized, double-masked, placebo-controlled trial.
Participants:
Thirty-nine thousand eight hundred seventy-six apparently healthy female health professionals aged 45 years or older.
Intervention:
Participants were assigned randomly to receive either 600 IU of natural-source vitamin E on alternate days or placebo.
Main Outcome Measures:
Incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.
Results:
After 10 years of treatment and follow-up, there were 117 cases of AMD in the vitamin E group and 128 cases in the placebo group (relative risk, 0.93; 95% confidence interval, 0.72-1.19).
Conclusions:
In a large-scale randomized trial of female health professionals, long-term alternate-day use of 600 IU of natural-source vitamin E had no large beneficial or harmful effect on risk of AMD.
