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Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
[Allergic risk during paediatric anaesthesia]
1Inserm U970, service d'anesthésie-réanimation chirurgicale, Samu de Paris, hôpital Necker-Enfants-Malades, AP-HP, université Paris Descartes, 149, rue de Sèvres, 75743 Paris cedex 15, France. pascale.dewachter@yahoo.fr
Insights
Paediatric anaesthesia allergic reactions are rare, with latex hypersensitivity being more common than neuromuscular blocking agents (NMBAs). Implementing a latex-free environment is crucial for reducing allergic risk in children during anaesthesia.
Area of Science:
- Anesthesiology
- Allergology
- Pediatric Medicine
Context:
- Allergic reactions pose a risk during pediatric anesthesia.
- Understanding the incidence and causes of these reactions is vital for patient safety.
Purpose:
- To review and propose management strategies for allergic risks in pediatric anesthesia.
- To analyze the literature on allergic reactions during anesthesia in children.
Summary:
- Anaphylactic reactions occur in approximately 1 in 7741 pediatric anesthetic procedures.
- Latex anaphylaxis is a significant concern (1 in 10,159 procedures), while reactions to neuromuscular blocking agents (NMBAs) are rare (1 in 81,275 procedures).
- Management involves clinical assessment using scales like Ring and Messmer, with epinephrine as first-line treatment for severe reactions, and allergological evaluation to identify causative agents.
Impact:
- Highlights the importance of latex-free environments to mitigate allergic risks in pediatric anesthesia.
- Provides insights into the differential incidence and management of allergic reactions to latex versus NMBAs in children.
- Emphasizes the role of prompt diagnosis and appropriate treatment, including allergological workup, for hypersensitivity reactions during pediatric anesthesia.
Objectives:
To propose the different modalities of management of the allergic risk occurring during paediatric anaesthesia.
Study Design:
Literature analysis.
Methods:
Literature research using the Medline((R)) database and MeSH format according to keywords, including publications in French and English since 1982.
Results:
The overall incidence for anaphylactic reactions was estimated at one in 7741 anaesthetic procedures during paediatric anaesthesia. Latex anaphylaxis was mostly involved with an incidence at one in 10,159 anesthetic procedures. The risk factors of latex sensitization are known. Primary latex prophylaxis is efficient in patients at risk of latex sensitization. In contrast to adults, neuromuscular blocking agents (NMBAs) are rarely involved in children, with an incidence at 1 in 81,275 anaesthetic procedures. The Ring and Messmer clinical scale allows quantifying the severity and helps managing the care of immediate hypersensitivity reactions. Clinical symptoms associate cardiovascular, respiratory and cutaneous-mucous signs according to different severity grades. Epinephrine associated to fluid loading, remains the first-line agent in case of severe reactions. The allergological assessment is key to the management of these reactions and is required in order to identify the mechanism of the reaction and the culprit drug or substance involved.
Conclusions:
Allergic reactions to NMBAs occurring during paediatric anaesthesia are rare whereas those with latex are more frequent. Therefore, the reduction of the allergic risk during paediatric anaesthesia essentially requires a latex-free environment.
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