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04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Elevation of serum immunoglobulin G in Hashimoto's thyroiditis and decrease after treatment with L-thyroxine in
Keishi Yamauchi1, Takashi Yamada, Akira Sato
1Department of Diabetes & Endocrinology, Nagano Red Cross Hospital, Nagano. keishi@nagano-med.jrc.or.jp
Internal Medicine (Tokyo, Japan)
|February 16, 2010
Summary
Serum immunoglobulin G (IgG) is elevated in Hashimoto
Area of Science:
- Endocrinology
- Immunology
- Thyroidology
Background:
- Hashimoto's thyroiditis is an autoimmune disorder affecting the thyroid gland.
- Elevated immunoglobulin G (IgG) levels are frequently observed in autoimmune conditions.
Purpose of the Study:
- To investigate the prevalence and levels of elevated serum IgG in Hashimoto's thyroiditis.
- To assess the impact of L-thyroxine (T4) treatment on serum IgG in these patients.
Main Methods:
- Retrospective analysis of 97 Hashimoto's thyroiditis patients, 104 simple goiter patients, and 75 controls.
- Measurement of serum total T4, TSH, MHA titer, and IgG in all subjects.
Main Results:
- Significantly elevated IgG in Hashimoto's thyroiditis patients, especially those with hypothyroidism.
- Negative correlation between serum total T4 and IgG; positive correlation between TSH and IgG.
- Positive correlation between MHA titer and IgG; L-T4 treatment reduced IgG in hypothyroid patients.
Conclusions:
- Serum IgG is increased in Hashimoto's thyroiditis, particularly in hypothyroid cases.
- L-thyroxine treatment effectively lowers IgG levels in hypothyroid Hashimoto's patients.
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