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Updated: Jun 16, 2026
07:15
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Synovial sarcoma of the chest wall
Daigo Kawano1, Ichiro Yoshino, Fumihiro Shoji
1Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan. daigo-k9@surg2.med.kyushu-u.ac.jp
General Thoracic and Cardiovascular Surgery
|February 16, 2010
Summary
This case report details a rare chest wall synovial sarcoma in a patient with a history of lung cancer. The tumor, identified as biphasic synovial sarcoma with SYT-SSX1 fusion, required surgical resection.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Synovial sarcoma is a rare soft tissue sarcoma.
- Chest wall tumors are uncommon, and synovial sarcoma of the chest wall is exceptionally rare.
- This report focuses on a specific subtype and its genetic markers.
Observation:
- A 71-year-old woman with a history of lung cancer developed a chest wall mass.
- Initial diagnosis via aspiration biopsy was synovial sarcoma.
- Pathology confirmed a biphasic-type synovial sarcoma.
Findings:
- Polymerase chain reaction detected SYT-SSX1 fusion gene transcripts in the tumor.
- The SYT-SSX1 fusion gene is associated with a poorer clinical outcome compared to SYT-SSX2.
- The patient underwent surgical resection for the chest wall tumor.
Implications:
- Early detection and accurate diagnosis are crucial for rare tumors like chest wall synovial sarcoma.
- Genetic profiling (SYT-SSX1) can inform prognosis and treatment strategies.
- Long-term surveillance is recommended due to the potential for recurrence.
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