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Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Partial Lobular Hepatectomy: A Surgical Model for Morphologic Liver Regeneration

Published on: May 31, 2018

Neutrophil phenotype and function in partial hepatectomy in man.

Katharina Holzer¹, Dennis Hofmann, Elsie Oppermann

¹Department of General Surgery, Johann-Wolfgang Goethe-University, Theodor- Stern- Kai 7, 60590, Frankfurt, Germany. Holzer@em.uni-frankfurt.de

Langenbeck'S Archives of Surgery

|February 16, 2010

Summary

Partial hepatectomy alters neutrophil phenotype and function. Neutrophil adhesion molecules increase, while Fcy receptors decrease, impacting host defense during liver surgery.

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Area of Science:

Immunology
Surgical Oncology
Hepatobiliary Surgery

Background:

Postoperative infection is a major complication of hepatic resections.
Neutrophil function is critical for host defense against infection.
Understanding neutrophil behavior during liver surgery is essential for improving patient outcomes.

Purpose of the Study:

To characterize changes in neutrophil phenotype and function during partial hepatectomy.
To investigate the impact of liver resection and Pringle maneuver on neutrophil adhesion molecules, Fcy receptors, and phagocytosis.

Main Methods:

Blood samples were collected from 14 patients undergoing partial liver resection at various time points.
Neutrophil adhesion molecules (CD 62, CD 18) and Fcy receptors (CD 16, CD 32) were analyzed using fluorescence-activated cell sorter analysis.
Neutrophil phagocytosis and oxygen radical generation were measured.

Main Results:

Upregulation of CD 62 and CD 18 on neutrophils was observed during and after liver resection.
Fcy receptors (CD16, CD32) were downregulated after the Pringle maneuver release, but neutrophil phagocytosis remained unaffected.
Spontaneous oxygen radical production peaked post-Pringle maneuver release, while stimulated production was depressed.

Conclusions:

Partial hepatectomy significantly alters neutrophil phenotype in humans.
Neutrophil function shows less significant changes compared to phenotype alterations after liver resection.
These findings provide insights into neutrophil behavior during hepatic surgery and potential implications for infection risk.