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Implications of Cheyne-Stokes breathing in advanced systolic heart failure

Offer Amir1, Daniel Reisfeld, Hila Sberro

  • 1Department of Cardiology, Lin Medical Center and Lady Davis Carmel Medical Center, Yocheced 10 street, Haifa, Israel. offeram@012.net.il

Clinical Cardiology
|February 16, 2010
PubMed

Insights

Cheyne-Stokes breathing (CSB) is highly prevalent in advanced heart failure (HF) patients. Longer CSB duration correlates with higher NT-proBNP levels and increased 6-month mortality, indicating its prognostic significance.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Pulmonology

Background:

  • Cheyne-Stokes breathing (CSB) is a known phenomenon in heart failure (HF) patients.
  • Its exact prevalence and prognostic impact in advanced HF remain unclear.

Purpose of the Study:

  • To determine the prevalence of nocturnal CSB in advanced HF.
  • To investigate the association between CSB and prognostic indicators, including mortality.

Main Methods:

  • Ambulatory polysomnography was conducted on 71 advanced systolic HF patients.
  • Sleep data, clinical information, and 6-month mortality were analyzed.

Main Results:

  • All patients exhibited CSB, with a mean duration of 1 hour.
  • CSB duration significantly correlated with elevated NT-proBNP levels (r=0.5, P<.0001).
  • Kaplan-Meier analysis revealed a significant association between CSB duration and 6-month mortality (P=.03).

Conclusions:

  • Nocturnal CSB is highly prevalent in advanced HF, exceeding prior estimates.
  • CSB duration is a significant predictor of elevated NT-proBNP and increased 6-month mortality in this population.
Abstract

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