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Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
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Published on: November 9, 2016

Intraperitoneal drug therapy: an advantage.

Kunal Chaudhary1, Shadi Haddadin, Ravi Nistala

  • 1Clinical Medicine, University of Missouri-Columbia School of Medicine, Division of Nephrology and Hypertension, Harry S Truman VA Medical Center, 800 Hospital Dr., Columbia, MO 65201, USA. chaudharyk@health.missouri.edu

Current Clinical Pharmacology
|February 17, 2010
PubMed
Summary
This summary is machine-generated.

The intraperitoneal (IP) route offers an alternative drug delivery method for conditions within the abdominal cavity. This review explores IP drug therapy

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Area of Science:

  • Pharmacology
  • Nephrology
  • Oncology

Background:

  • The peritoneal cavity, used for peritoneal dialysis (PD), serves as a portal for drug delivery.
  • Intraperitoneal (IP) administration is established for antibiotics to treat peritonitis in PD patients.
  • Emerging use of IP chemotherapy shows promise for intra-abdominal and peritoneal surface malignancies.

Purpose of the Study:

  • To review the utility of the intraperitoneal route for drug delivery.
  • To examine factors influencing drug transfer within the peritoneal cavity.
  • To discuss strategies for enhancing the efficacy of IP drug therapy.

Main Methods:

  • Review of existing literature on intraperitoneal drug administration.
  • Analysis of physiological factors affecting peritoneal drug transfer.
  • Evaluation of clinical outcomes for IP chemotherapy and antibiotic therapy.

Main Results:

  • The IP route is effective for delivering medications directly to the peritoneal cavity.
  • Drug transfer is influenced by peritoneal inflammation, surface area, blood flow, and contact time.
  • Perioperative IP chemotherapy has demonstrated positive results for peritoneal malignancies.

Conclusions:

  • Intraperitoneal drug therapy is a viable alternative to conventional routes.
  • It is particularly effective when the target is within the peritoneal cavity or adjacent tissues.
  • Understanding influencing factors can optimize IP drug delivery strategies.