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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Tumor Immunotherapy

Tumor Immunotherapy

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Defense Against Bacterial Pathogens

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Phagocytes
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Colonisation of Pathogens

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Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...

Modified-Release Drug Delivery Systems: Site-Targeted

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The Tumor Microenvironment

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Related Experiment Video

Updated: Jun 16, 2026

Bioluminescent Bacterial Imaging In Vivo

Bioluminescent Bacterial Imaging In Vivo

Published on: November 4, 2012

Tumour targeting with systemically administered bacteria.

David Morrissey¹, Gerald C O'Sullivan, Mark Tangney

¹Cork Cancer Research Centre, Mercy University Hospital, University College Cork, Ireland.

Current Gene Therapy

|February 17, 2010

Summary

This summary is machine-generated.

Bacteria show natural tumor-homing abilities, offering a novel approach for targeted cancer therapy and diagnostics. This strategy utilizes bacteria to deliver anti-cancer genes or therapeutic proteins directly to tumors, minimizing side effects.

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Bioluminescent Bacterial Imaging In Vivo

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Published on: November 4, 2012

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

Area of Science:

Oncology
Microbiology
Biotechnology

Background:

Targeted cancer treatment remains a significant challenge.
Bacteria possess natural tumor-homing and replication capabilities.
This presents an opportunity for novel anti-cancer strategies.

Purpose of the Study:

To review preclinical data on bacteria as tumor-targeting agents.
To discuss recent advancements in this field.
To outline future directions for clinical translation.

Main Methods:

Systemic administration of bacteria in preclinical models.
Utilizing reporter gene tagging for real-time visualization.
Investigating bacterial colonization in various tumor types.

Main Results:

Bacteria selectively colonize and replicate within tumor tissues.
Bacterial colonization is observed across different tumor origins and bacterial species.
Tumor microenvironment factors beyond hypoxia influence bacterial localization.

Conclusions:

Bacteria show significant potential as a platform for targeted cancer therapy and diagnostics.
Further research is needed to translate these findings into clinical applications.
Bacterial-based therapies offer a promising avenue for improving cancer treatment outcomes.