Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Novel Antigonadotropic Role of Thyroid Stimulating Hormone on Leydig Cell-Derived Mouse Leydig Tumor Cells-1 Line.

Annals of the National Academy of Medical Sciences (India)·2020
Same author

Novel Use of a Closed Liposuction System: Treatment of an Acute Morel-Lavallée Lesion of the Upper Extremity.

Cureus·2020
Same author

Comorbid Diabetes in Inflammatory Bowel Disease Predicts Adverse Disease-Related Outcomes and Infectious Complications.

Digestive diseases and sciences·2020
Same author

Emerging manufacturers engagements in the COVID -19 vaccine research, development and supply.

Vaccine·2020
Same author

Development of CuAg/Cu<sub>2</sub>O nanoparticles on carbon nitride surface for methanol oxidation and selective conversion of carbon dioxide into formate.

Journal of colloid and interface science·2020
Same author

Scattered Skin Eruptions in a Patient With Inflammatory Bowel Disease.

Gastroenterology·2020
Same journal

Efficacy of higher-dose versus lower-dose corticosteroids in community-acquired pneumonia: a systematic review and network meta-analysis.

Critical care (London, England)·2026
Same journal

Prehospital lactate, transfer time, and early mortality across emergency diagnostic categories.

Critical care (London, England)·2026
Same journal

Correction: VExUS score: optimizing its use in perioperative and critical care management.

Critical care (London, England)·2026
Same journal

Optimizing β-lactam antibiotics with the highest concentration-for continuous infusion reduce carbon footprint in intensive care.

Critical care (London, England)·2026
Same journal

Physiological and clinical effects of selected airway clearance techniques in mechanically ventilated adult ICU patients: a systematic review and synthesis without meta-analysis.

Critical care (London, England)·2026
Same journal

How we use the neurological pupil index (NPi).

Critical care (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature
05:33

Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature

Published on: June 19, 2019

Determining relevant cortisol concentrations in critically ill patients.

Rizwan A Manji, Anand Kumar

    Critical Care (London, England)
    |February 17, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing adrenal insufficiency in critically ill patients is challenging. A new study explores measuring tissue cortisol as a potential, less invasive alternative to plasma-free cortisol testing.

    More Related Videos

    Cortisol Measurement in Koala (Phascolarctos cinereus) Fur
    09:11

    Cortisol Measurement in Koala (Phascolarctos cinereus) Fur

    Published on: August 23, 2019

    Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
    08:25

    Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

    Published on: December 18, 2013

    Related Experiment Videos

    Last Updated: Jun 16, 2026

    Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature
    05:33

    Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature

    Published on: June 19, 2019

    Cortisol Measurement in Koala (Phascolarctos cinereus) Fur
    09:11

    Cortisol Measurement in Koala (Phascolarctos cinereus) Fur

    Published on: August 23, 2019

    Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
    08:25

    Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers

    Published on: December 18, 2013

    Area of Science:

    • Endocrinology
    • Critical Care Medicine
    • Burn Injury Research

    Background:

    • Adrenal function is vital for critically ill patients' survival.
    • Accurate diagnosis of adrenal insufficiency remains a clinical challenge.
    • Existing diagnostic methods for adrenal insufficiency have limitations.

    Discussion:

    • This study investigates tissue cortisol measurements as a potential surrogate for plasma-free cortisol.
    • The research focuses on burn patients, a population with unique physiological stress.
    • Technical difficulties associated with serum-free cortisol assays necessitate alternative diagnostic approaches.

    Key Insights:

    • Measuring tissue cortisol may offer a feasible alternative for assessing adrenal function.
    • Tissue cortisol levels could potentially serve as a surrogate marker for plasma-free cortisol.
    • Further validation is needed to establish tissue cortisol as a reliable diagnostic tool.

    Outlook:

    • Future research should focus on validating tissue cortisol measurements across diverse patient populations.
    • Developing standardized protocols for tissue cortisol analysis is crucial.
    • This approach could improve the diagnosis and management of adrenal insufficiency in critical care settings.