Related Experiment Video
Updated: Jun 16, 2026
05:19
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Urolith masquerading as severe acute radiation toxicity: case report.
Daniel Toguri1, D Andrew Loblaw, Robert K Nam
1Clinical Clerk, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.
The Canadian Journal of Urology
|February 17, 2010
Summary
Severe urinary symptoms during prostate cancer radiotherapy can indicate bladder stones (urolithiasis). Early diagnosis and treatment, such as cystolitholapaxy, are crucial for symptom resolution in patients undergoing radiation therapy.
Area of Science:
- Oncology
- Urology
Background:
- Postoperative radiotherapy following radical prostatectomy improves outcomes for select prostate cancer patients.
- Common side effects include mild to moderate urinary and gastrointestinal symptoms, and fatigue.
Observation:
- A patient undergoing salvage radiotherapy for prostate cancer developed severe, culture-negative urinary symptoms early in treatment.
- Symptoms included hematuria, dysuria, and passage of cellular debris, unresponsive to radiation therapy breaks.
Findings:
- Imaging revealed a 3.5 cm bladder stone (urolith).
- Urinary symptoms resolved completely after laser cystoscopy and cystolitholapaxy (stone removal).
Implications:
- Urolithiasis is a rare but important consideration in patients experiencing severe, early, culture-negative dysuria during prostate cancer radiotherapy.
- Prompt identification and management of bladder stones can alleviate radiotherapy-induced urinary complications.
Related Concept Videos
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
01:30Urinary Tract Calculi III: Medical Management
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
01:28Urinary Tract Calculi V: Nursing Management
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
01:25Urinary Tract Calculi VI: Surgical Management
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...