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Related Experiment Video

Updated: Jun 16, 2026

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Optically guided controlled release from liposomes with tunable plasmonic nanobubbles.

Lindsey J E Anderson1, Eric Hansen, Ekaterina Y Lukianova-Hleb

  • 1Rice University, 6100 Main Street, TX 77005, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 17, 2010
PubMed
Summary

Researchers developed a new optically guided method for controlled release from liposomes using gold nanoparticles and laser pulses. This technique precisely releases molecular contents via laser-induced nanobubbles, offering tunable and non-damaging cargo delivery.

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Last Updated: Jun 16, 2026

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment
09:13

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications
08:19

Controllable Nucleation of Cavitation from Plasmonic Gold Nanoparticles for Enhancing High Intensity Focused Ultrasound Applications

Published on: October 5, 2018

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Controlled release systems are crucial for targeted drug delivery and molecular payload manipulation.
  • Existing methods often face challenges with precision, cargo integrity, or external energy requirements.
  • Liposomes are versatile nanocarriers for various molecular loads.

Purpose of the Study:

  • To evaluate a novel optically guided controlled release method using gold nanoparticles (NPs) and liposomes.
  • To investigate the mechanism and control parameters of laser-induced plasmonic nanobubble formation for liposome disruption.
  • To demonstrate real-time monitoring and guidance of molecular release.

Main Methods:

  • Liposomes encapsulating molecular cargo and gold nanoparticles were subjected to short laser pulses.
  • Plasmonic nanobubbles were generated around NPs, inducing liposome disruption and content release.
  • Release efficacy was tuned by laser fluence, and monitored using fluorescence microscopy and optical scattering.

Main Results:

  • The method successfully induced controlled release of molecular contents from individual liposomes.
  • Release efficacy correlated with nanobubble lifetime and size, controllable via laser fluence.
  • The process was identified as mechanical, nonthermal, rapid (millisecond timescale), and preserved cargo integrity.

Conclusions:

  • Optically guided controlled release using plasmonic nanobubbles offers a precise and efficient method for liposome content ejection.
  • This technique provides a tunable, non-damaging, and rapid approach for molecular cargo delivery.
  • The correlation between optical scattering and release allows for real-time guidance of the release process.