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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Prevalence and phylogenetic analysis of rotavirus genotypes in Thailand between 2007 and 2009

Kamonwan Khananurak1, Viboonsak Vutithanachot, Nipat Simakachorn

  • 1Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|February 17, 2010
PubMed

Insights

Rotavirus, a leading cause of severe diarrhea in children, shows changing genotypes in Thailand. Understanding these rotavirus strains is crucial for effective prevention and vaccine strategies.

Area of Science:

  • Virology
  • Public Health
  • Epidemiology

Background:

  • Rotaviruses are a primary cause of severe diarrhea in infants and young children globally, posing a significant public health challenge in Thailand.
  • Rotavirus infections account for a substantial proportion of diarrheal diseases among hospitalized children in Thailand.

Purpose of the Study:

  • To analyze the distribution and molecular characteristics of rotaviruses circulating in Thai infants and young children with diarrhea.
  • To investigate the genetic diversity and phylogenetic relationships of rotavirus strains in Thailand.

Main Methods:

  • Fecal specimens from 557 children with diarrhea were analyzed using reverse transcription-polymerase chain reaction (RT-PCR).
  • Rotavirus G and P genotypes were identified, and phylogenetic analysis was performed on selected isolates.

Main Results:

  • Human rotavirus group A was detected in 28.4% of specimens, with peak incidence from December to March.
  • The most prevalent strains were G1P[8] (49.4%), followed by G9P[8] (22.2%), and G2P[4] (20.2%).
  • Emergence of G12 strains was observed, with phylogenetic analysis indicating close relations to Indian isolates.

Conclusions:

  • The study highlights the dynamic and changing nature of rotavirus genotypes circulating in Thailand.
  • Genetic links between Thai rotavirus isolates and those from other countries underscore the importance of considering global dissemination for prevention and vaccine strategies.

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