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Factors attributable to the level of exhaled nitric oxide in asthmatic children

P Banovcin1, M Jesenak, Z Michnova

  • 1Department of Pediatrics, Comenuis University in Bratislava, Jessenius School of Medicine, Kollarova 2 St., 036 59 Martin, Slovakia.

European Journal of Medical Research
|February 17, 2010
PubMed

Insights

Fractioned exhaled nitric oxide (FeNO) levels vary in children with asthma. FeNO correlates with blood eosinophils, age, and lung function, aiding asthma management.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Biomarkers in Respiratory Diseases

Background:

  • Asthma in children presents with heterogeneous symptoms, impacting clinical management.
  • Fractioned exhaled nitric oxide (FeNO) is a key marker for airway inflammation in pediatric asthma.
  • FeNO aids in predicting exacerbations and guiding corticosteroid therapy in asthmatic children.

Purpose of the Study:

  • To investigate factors influencing the variability of FeNO in children under diverse clinical and laboratory conditions.
  • To analyze the relationship between FeNO and other biomarkers in pediatric asthma.

Main Methods:

  • A cohort of 222 asthmatic children and 27 healthy controls was studied.
  • Participants underwent FeNO measurement, exhaled carbon monoxide assessment, asthma control testing, blood analysis, skin prick tests, and spirometry.
  • Data were analyzed to identify correlations between FeNO and various clinical/laboratory parameters.

Main Results:

  • Asthmatic children exhibited elevated FeNO, exhaled carbon monoxide, total serum IgE, and eosinophil counts compared to controls.
  • Boys demonstrated higher FeNO levels than girls.
  • Significant positive correlations were observed between FeNO and blood eosinophil percentage, predicted forced vital capacity, total serum IgE, and age.

Conclusions:

  • Pediatric asthma phenotypes are associated with distinct clinical and laboratory test patterns.
  • FeNO shows variable correlations with total serum IgE, blood eosinophilia, age, and spirometry parameters.
  • Atopy, allergic rhinitis/rhinoconjunctivitis, and other factors are crucial for interpreting FeNO in managing childhood asthma.
Abstract

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