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Possible role of matrix metalloproteinase in osteolytic intracranial meningiomas

Hyung-Sik Moon1, Shin Jung, Tae-Young Jung

  • 1Department of Neurosurgery, Chonnam National University Hwasun Hospital & Medical School, Gwangju, Korea.

Journal of Korean Neurosurgical Society
|February 17, 2010
PubMed
Abstract

Insights

Extensive skull bone destruction in meningioma patients is rare but not always malignant. Matrix metalloproteinase-2 (MMP-2) expression may be linked to osteolysis, particularly in extracranial tumors.

Area of Science:

  • Neurosurgery
  • Oncology
  • Pathology

Background:

  • Bone abnormalities like hyperostosis and endostosis are common in meningioma.
  • Extensive osteolytic bone destruction is an unusual finding in meningioma cases.

Purpose of the Study:

  • To report six cases of intracranial meningioma with osteolytic skull lesions.
  • To investigate the potential role of matrix metalloproteinases (MMPs) in meningioma-associated osteolysis.

Main Methods:

  • Classified six patients based on osteolytic bone destruction severity and tumor location (intracranial/extracranial).
  • Assessed matrix metalloproteinase (MMP) expression using gelatin zymography, RT-PCR, and immunohistochemistry.

Main Results:

  • Histology revealed four benign and two atypical meningiomas; prognosis was generally good.
  • High levels of MMP-2 were detected in extracranial masses, with some MMP-9 observed.
  • MMP-2 expression correlated with bone destruction, particularly near the affected bone areas.

Conclusions:

  • Skull osteolysis in meningioma patients may not indicate malignancy or poor prognosis.
  • Extracranial invasion and osteolysis appear associated with MMP-2 expression in meningiomas.
Keywords:
Matrix metalloproteinaseMeningiomaOsteolytic

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