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Related Experiment Video

Updated: Jun 16, 2026

Directed Evolution Method in Saccharomyces cerevisiae: Mutant Library Creation and Screening
10:50

Directed Evolution Method in Saccharomyces cerevisiae: Mutant Library Creation and Screening

Published on: April 1, 2016

New mutant phenotype data curation system in the Saccharomyces Genome Database.

Maria C Costanzo1, Marek S Skrzypek, Robert Nash

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120 and Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA.

Database : the Journal of Biological Databases and Curation
|February 17, 2010
PubMed
Summary

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The Saccharomyces Genome Database (SGD) now uses a controlled vocabulary for yeast mutant phenotypes, improving data searching and comparison. This system enhances the understanding of gene functions and biological processes in Saccharomyces cerevisiae.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Mutant phenotype screens are crucial for yeast molecular biology research, aiding in the elucidation of gene functions.
  • The Saccharomyces Genome Database (SGD) is a key resource for organizing and displaying genetic and molecular information for Saccharomyces cerevisiae.

Purpose of the Study:

  • To develop a standardized system for capturing and searching yeast mutant phenotype data.
  • To enhance the usability and accessibility of phenotype information within the Saccharomyces Genome Database.

Main Methods:

  • Implementation of a controlled-vocabulary system using 'observables' and 'qualifiers' to represent phenotype data.
  • Integration of additional metadata such as strain background, allele name, and experimental conditions.

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Last Updated: Jun 16, 2026

Directed Evolution Method in Saccharomyces cerevisiae: Mutant Library Creation and Screening
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Directed Evolution Method in Saccharomyces cerevisiae: Mutant Library Creation and Screening

Published on: April 1, 2016

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
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A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Microarray Analysis for Saccharomyces cerevisiae
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Microarray Analysis for Saccharomyces cerevisiae

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  • Development of searchable and downloadable phenotype data within SGD.

    • Main Results:

    • A new controlled-vocabulary system for capturing yeast mutant phenotypes has been successfully implemented.
    • Phenotype information is now more consistently represented, facilitating cross-gene comparisons.
    • SGD displays summarized and detailed phenotype data, enhancing user access and data mining capabilities.

    Conclusions:

    • The new phenotype annotation system significantly improves the searchability and comparability of mutant data in SGD.
    • This structured data approach will facilitate future integration with other functional genomics information.
    • Enhanced data organization in SGD supports ongoing research into Saccharomyces cerevisiae gene function.