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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: Jun 16, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
09:11

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

[Core needle biopsy twice negative with rising PSA level. Does imaging help?].

T Loch1

  • 1Klinik für Urologie, Diakonissenkrankenhaus Flensburg, Lehrkrankenhaus der Christian-Albrechts-Universität, Knuthstrasse 1, 24939 Flensburg. lochti@diako.de

Der Urologe. Ausg. A
|February 17, 2010
PubMed
Summary

Standard prostate cancer detection involves multiple biopsies. Innovative imaging after negative biopsies significantly improves cancer detection rates, questioning the reliability of systematic sampling alone.

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Related Experiment Videos

Last Updated: Jun 16, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
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Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Context:

  • Current prostate cancer guidelines recommend 10-12 transrectal ultrasound-guided systematic biopsies per session.
  • Increasing biopsy numbers in repeat sessions aims to improve diagnostic certainty, especially with rising PSA levels.
  • Evidence suggests diminishing returns from additional systematic biopsies after the initial two sessions.

Purpose:

  • To evaluate the efficacy of innovative imaging techniques in detecting prostate cancer after multiple negative systematic biopsies.
  • To compare the diagnostic yield of targeted biopsies guided by imaging versus further systematic sampling.

Summary:

  • A prospective trial involving 132 patients with an average of 12 negative biopsies demonstrated high cancer detection rates (66/132) using 1-6 targeted biopsies guided by innovative imaging.
  • This suggests that systematic biopsies may not reliably exclude prostate cancer, particularly after multiple negative results.
  • Targeted imaging offers a potential quality improvement for diagnostic certainty in these cases.

Impact:

  • Highlights the limitations of relying solely on systematic biopsies for prostate cancer diagnosis.
  • Suggests that advanced imaging techniques could enhance cancer detection in patients with persistently negative biopsy results.
  • Emphasizes the need for prospective clinical validation of novel imaging methods before widespread adoption.