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Published on: February 10, 2023
Relationship between proteinuria and venous thromboembolism.
Shumei Kato1, Svetlana Chernyavsky, Joji Erik Tokita
1Department of Medicine, Beth Israel Medical Center, University Hospital and Manhattan Campus for the Albert Einstein College of Medicine, First Avenue at 16th Street, New York, NY 10003, USA. shkato@chpnet.org
Journal of Thrombosis and Thrombolysis
|February 17, 2010
Summary
Proteinuria, or protein in urine, significantly increases the risk of developing venous thromboembolism (VTE). This finding highlights proteinuria as a key predictor for VTE in patients.
Area of Science:
- Nephrology
- Hematology
- Medical Diagnostics
Background:
- Nephrotic syndrome is a known risk factor for venous thromboembolism (VTE).
- Urine loss of antithrombin III and coagulation system activation contribute to VTE risk in nephrotic syndrome.
- The predictive role of proteinuria degree for VTE development requires further investigation.
Purpose of the Study:
- To investigate the hypothesis that the degree of proteinuria predicts the development of venous thromboembolism (VTE).
- To assess the association between proteinuria and VTE risk, independent of other risk factors.
Main Methods:
- Retrospective case-controlled study of 284 VTE patients and 280 matched controls.
- Analysis of 1,647 radiology reports for CT angiography and Doppler sonograms for VTE diagnosis.
- Data collected included proteinuria, serum protein/albumin levels, VTE risk factors, and renal function.
Main Results:
- Patients with proteinuria had a 3.4-fold increased risk of VTE compared to those without proteinuria (OR 3.4, 95% CI [2.4, 5.0]).
- This association remained significant after adjusting for other VTE risk factors.
- Proteinuria was identified as an independent risk factor for VTE.
Conclusions:
- Proteinuria is a significant predictor of venous thromboembolism (VTE).
- Clinical monitoring for VTE should consider the presence and degree of proteinuria.
- Further research into the mechanisms linking proteinuria and VTE is warranted.
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