Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
Diffusion01:21

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Iterated Integrals and Fubini's Theorem01:28

Iterated Integrals and Fubini's Theorem

A double integral generalizes the concept of a single-variable integral to functions of two variables, enabling the computation of the volume beneath a surface z = f(x, y) over a planar region R . For a rectangular region defined by a ≤ x ≤ b and c ≤ y ≤ d, and for functions continuous on this domain, the double integral can be evaluated as an iterated integral. This approach simplifies computation by reducing the problem to successive integrations with respect to one variable at a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting the topography of fitness landscapes from the structure of genotype-phenotype maps.

Genetics·2026
Same author

Controlling DNA-RNA strand displacement kinetics with base distribution.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Deep neural networks have an inbuilt Occam's razor.

Nature communications·2025
Same author

Publisher Correction: Unified framework for laser-induced transient bubble dynamics within microchannels.

Scientific reports·2024
Same author

20-Fold Increased Limiting Currents in Oxygen Reduction with Cu-tmpa by Replacing Flow-By with Flow-Through Electrodes.

ACS sustainable chemistry & engineering·2024
Same author

Unified framework for laser-induced transient bubble dynamics within microchannels.

Scientific reports·2024
Same journal

Ambient stability and surface adhesion of 2D polyaramid nanofilms.

Faraday discussions·2026
Same journal

Spiers Memorial Lecture: Spin-mediated promotion of magnetic metal catalysts.

Faraday discussions·2026
Same journal

Helium spin-echo as a surface-sensitive probe of vibrational energy dissipation.

Faraday discussions·2026
Same journal

Near-infrared vibrational second harmonic generation: a new nonlinear interfacial vibrational spectroscopy.

Faraday discussions·2026
Same journal

CO on a Rh/Fe<sub>3</sub>O<sub>4</sub> single-atom catalyst: high-resolution infrared spectroscopy and near-ambient-pressure scanning tunnelling microscopy.

Faraday discussions·2026
Same journal

Evolution of size-selected Pt cluster catalysts on prototypical oxide supports.

Faraday discussions·2026
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

The crossover from single file to Fickian diffusion.

Jimaan Sané1, Johan T Padding, Ard A Louis

  • 1Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford, OX1 3NP, United Kingdom.

Faraday Discussions
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

We studied how colloidal particles transition from single-file diffusion to normal diffusion in channels. Hydrodynamic interactions significantly impact this crossover, especially in narrow channels due to lubrication forces.

More Related Videos

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

Related Experiment Videos

Last Updated: Jun 16, 2026

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
10:20

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

Area of Science:

  • Physics
  • Physical Chemistry
  • Soft Matter Physics

Background:

  • Colloidal particles in confined geometries exhibit unique transport phenomena.
  • Understanding the transition from sub-diffusive to normal diffusion is crucial for nanoscale transport.

Purpose of the Study:

  • To investigate the crossover from single-file diffusion to Fickian diffusion in colloidal systems.
  • To analyze the influence of channel width and hydrodynamic interactions on particle mobility.

Main Methods:

  • Comparison of Brownian dynamics simulations with hybrid molecular dynamics and mesoscopic simulations.
  • Analysis of mean-square displacement scaling with time.
  • Modeling particle hopping dynamics in narrow channels.

Main Results:

  • Single-file diffusion (scaling as t^1/2) transitions to Fickian diffusion (scaling as t).
  • Hydrodynamic interactions significantly affect single-file mobility and the diffusion crossover.
  • In narrow channels (deltac << 1), particle hopping governs diffusion, with hopping time t(hop) ~ delta_c^(-2) for Brownian particles.
  • Hydrodynamics introduce a stronger dependence of t(hop) on channel width due to lubrication forces.

Conclusions:

  • The hard-rod model accurately describes single-file mobilities for disc-like particles.
  • Hydrodynamic interactions, particularly lubrication forces, play a critical role in the diffusion crossover in narrow channels.
  • Particle hopping dynamics are essential for understanding the transition to Fickian diffusion in confined colloidal systems.