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Updated: Jun 16, 2026

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Published on: July 22, 2015

Lateral pressure profiles in lipid monolayers.

Svetlana Baoukina¹, Siewert J Marrink, D Peter Tieleman

¹Department of Biological Sciences, University of Calgary, 2500 University Dr. NW, Calgary, AB, T2N 1N4, Canada.

Faraday Discussions

|February 18, 2010

Summary

This summary is machine-generated.

Molecular dynamics simulations reveal distinct lateral pressure profiles in lipid monolayers, differing from bilayers. These profiles are influenced by lipid composition and surface tension, offering insights into interfacial behavior.

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Area of Science:

Biophysics
Materials Science
Computational Chemistry

Background:

Lipid monolayers are crucial for biological membranes and technological applications.
Understanding their interfacial properties, like lateral pressure, is key to predicting their behavior.

Purpose of the Study:

To investigate the lateral pressure profiles in lipid monolayers at various interfaces.
To compare results from coarse-grained and atomistic molecular dynamics simulations.
To analyze the effects of surface tension and lipid composition on these profiles.

Main Methods:

Molecular dynamics simulations using both coarse-grained and atomistic models.
Analysis of lateral pressure profiles at oil/air, oil/water, and air/water interfaces.
Systematic variation of lipid composition and surface tension.

Main Results:

Lipid monolayer pressure profiles exhibit a headgroup/water pressure-interfacial tension-chain pressure pattern.
Unlike bilayers, pressure decreases towards chain free ends in monolayers.
An additional chain/air tension peak is observed at air/water interfaces.
Increased surface tension suppresses pressure peaks and alters interfacial tension.
Lipid composition significantly impacts all regions of the pressure profile.

Conclusions:

Both coarse-grained and atomistic models provide qualitatively similar insights into lipid monolayer lateral pressure.
Lateral pressure profiles are sensitive to interfacial conditions and molecular structure.
These findings contribute to a deeper understanding of lipid monolayer organization and function.