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Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 16, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

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Published on: May 10, 2024

[PPARgamma and cancer].

Hitoshi Nakagama¹

¹National Cancer Center Research Institute.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|February 18, 2010

Summary

Peroxisome proliferator-activated receptor gamma (PPARgamma) signaling influences cancer. Both activating and inhibiting PPARgamma shows potential for cancer chemoprevention and suppressing tumor invasion.

Area of Science:

Molecular biology
Oncology
Cell signaling

Context:

PPARgamma is upregulated in various cancers, including colon and breast cancer.
PPARgamma regulates adipocyte differentiation and cell growth.
Its role in cancer development is increasingly recognized.

Purpose:

To summarize the role of PPARgamma signaling in cancer development.
To discuss the potential of PPARgamma ligands for cancer chemoprevention.
To explore the dual role of PPARgamma agonists and antagonists in cancer.

Summary:

PPARgamma agonists demonstrate a growth-suppressive effect, notably in mouse colon cancer models.
Inhibition of PPARgamma signaling also exhibits suppressive effects on cancer cell invasion and metastasis.

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

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Both activation and inhibition of PPARgamma pathways warrant further investigation for therapeutic applications.

Impact:

Highlights the therapeutic potential of targeting PPARgamma signaling for cancer treatment and prevention.
Suggests a complex role for PPARgamma in tumorigenesis, requiring deeper molecular analysis.
Provides insights into novel strategies for cancer chemoprevention using PPARgamma ligands.