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Updated: Jun 16, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
[PPARgamma agonists as potential therapeutic drugs for allergic diseases]
Shigeharu Ueki1, Junichi Chihara
1Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Akita University Graduate School of Medicine.
Abstract:
The nuclear receptor PPARgamma exerts a potent anti-inflammatory effects on immune cells and connective tissue cells. Accumulating evidences indicate that pathophysiological contribution of PPARgamma in allergic disease including asthma. Most recently, clinical efficacy and tolerability of PPARgamma agonists for asthma or atopic dermatitis have been reported. PPARgamma agonists seem to be new therapeutic drugs for allergic diseases, although further studies are required. Here we discuss the outlook for clinical significance of PPARgamma agonists for allergic diseases.
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