Related Experiment Video

Updated: Jun 16, 2026

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
08:35

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Published on: January 4, 2012

[PPARgamma-gene therapy]

Kazufumi Katayama1, Atsushi Nakajima

  • 1Department of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 18, 2010
PubMed

Insights

Gene therapy using peroxisome proliferator-activated receptor gamma (PPARgamma) can restore anti-inflammatory processes. This approach offers a potential strategy for treating conditions linked to reduced PPARgamma expression.

Area of Science:

  • Molecular biology
  • Genetics
  • Immunology

Context:

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in various pathophysiological conditions.
  • PPARgamma plays critical roles in numerous biological processes.
  • Restoring PPARgamma function is a potential therapeutic target.

Purpose:

  • To review recent advancements in PPARgamma gene therapy.
  • To explore the molecular pathways regulated by PPARgamma.
  • To summarize findings on PPARgamma gene therapy efficacy.

Summary:

  • Gene delivery of PPARgamma can restore endogenous anti-inflammatory functions in mammalian tissues.
  • PPARgamma gene therapy shows promise in addressing conditions associated with reduced PPARgamma levels.
  • This review covers progress in PPARgamma gene therapy and its molecular mechanisms.

Impact:

  • Highlights the therapeutic potential of PPARgamma gene therapy.
  • Provides insights into PPARgamma's role in inflammation.
  • Informs future research directions in gene therapy for inflammatory diseases.

More Related Videos

piggyBac Transposon System Modification of Primary Human T Cells10:02

piggyBac Transposon System Modification of Primary Human T Cells

Published on: November 5, 2012

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...