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Updated: Jun 16, 2026

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound

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Multimodality tumor imaging targeting integrin alphavbeta3.

Weibo Cai¹, Sanjiv Sam Gambhir, Xiaoyuan Chen

¹Stanford University School of Medicine, Stanford, CA 94305-5484 , USA.

|February 18, 2010

Summary

Noninvasive imaging of integrin alphavbeta3 expression in tumors can reveal insights into angiogenesis and anti-angiogenic therapy. This approach aids in early cancer detection and drug development.

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Last Updated: Jun 16, 2026

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Area of Science:

Oncology
Molecular Imaging
Biochemistry

Background:

Integrin alphavbeta3 is crucial for tumor angiogenesis and metastasis.
Targeting integrin alphavbeta3 with antagonists can inhibit tumor growth and increase vascular permeability.

Purpose of the Study:

To review advances in multimodality imaging of tumor integrin alphavbeta3 expression.
To highlight the potential of in vivo imaging for understanding angiogenesis and anti-angiogenic therapy.

Main Methods:

Review of recent literature on imaging techniques.
Focus on magnetic resonance imaging (MRI), ultrasound, near-infrared (NIR) fluorescence, single photon emission computed tomography (SPECT), and positron emission tomography (PET).

Main Results:

Multimodality imaging offers quantitative assessment of integrin alphavbeta3 expression in vivo.
Imaging can aid in lesion detection, patient stratification, and treatment monitoring.

Conclusions:

Noninvasive imaging of integrin alphavbeta3 is valuable for cancer research and clinical applications.
This technology supports the development and validation of anti-integrin drugs and personalized cancer therapy.