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Allergic Reactions02:06

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Overview
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Antibody Structure01:10

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Related Experiment Video

Updated: Jun 16, 2026

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

Do allergic families avoid keeping furry pets?

R J Bertelsen1, K C L Carlsen, B Granum

  • 1Department of Environmental Immunology, Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, Oslo, Norway. randi.jacobsen.bertelsen@fhi.no

Indoor Air
|February 18, 2010
PubMed
Summary

Family pet ownership is linked to socio-economic factors, not typically to a child's asthma or allergies. Pet avoidance correlates with allergic rhinitis, but not asthma, highlighting the need for prospective pet-keeping data.

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Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: Jun 16, 2026

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI
07:31

Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI

Published on: November 1, 2014

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Environmental Health
  • Epidemiology
  • Pediatrics

Background:

  • Pet ownership is a common factor in households with children.
  • Previous studies on pet keeping and allergic disease development have yielded conflicting results.
  • Pet avoidance in families with allergic disease history may confound study findings.

Purpose of the Study:

  • To investigate the association between pet keeping and socio-economic factors in families with children.
  • To examine the relationship between pet ownership and the development of asthma and allergies in children.
  • To assess the impact of allergic disease on pet ownership and pet removal.

Main Methods:

  • A cohort of 1019 children in Oslo was followed until 10 years of age.
  • Data collected included pet ownership, socio-economic factors, and family history of allergic disease.
  • Retrospective reporting of pet keeping was analyzed, with attention to recall error.

Main Results:

  • A family history of asthma or rhinoconjunctivitis was not significantly associated with pet ownership at birth or pet removal by age 10.
  • Acquiring cats and dogs was less likely in children with allergic rhinoconjunctivitis, but not associated with asthma.
  • Socio-economic factors, including single parenthood and parental smoking, significantly influenced pet acquisition decisions.

Conclusions:

  • Allergic disease in a child does not commonly lead to pet removal.
  • Pet avoidance is linked to allergic rhinitis symptoms, but not asthma.
  • Socio-economic factors are strong predictors of pet keeping, underscoring the need for prospective data collection.