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Calcium oscillation associated with reduced protein kinase C activities in ras-transformed NIH3T3 cells
T Fu1, Y Sugimoto, T Oki
1Department of Biochemistry, Gifu University School of Medicine, Japan.
FEBS Letters
|April 9, 1991
Abstract:
We show here novel intracellular Ca2+ oscillation in v-K-ras-transformed NIH3T3 cells induced by mitogenic peptide hormones, bradykinin and bombesin, as well as fetal calf serum. Induction of the Ca2+ oscillation is strongly correlated with the malignant properties and inversely with PKC activities in vitro and in vivo. These results suggest that the mitogen-induced Ca2+ oscillation is negatively regulated by PKC, which modulates Ca2+ influx in v-K-ras-transformed NIH3T3 cells.