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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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[Kleine-Levin syndrome: a case report].

Y Richard1, M Le Galudec, S Saint-André

  • 1Jeune équipe Ethique, Professionnalisation, Santé (JE 2535), université de Bretagne occidentale, UFR médecine et sciences de la santé, Service hospitalo-universitaire de psychiatrie de l'enfant et de l'adolescent, hôpital de Bohars, CHU de Brest, France. richard@clinique-valjosselin.fr

L'Encephale
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

Kleine-Levin Syndrome (KLS) is a rare neurological disorder characterized by recurring episodes of excessive sleep, cognitive issues, and behavioral changes. This case highlights diagnostic challenges and the need for careful clinical evaluation, distinguishing KLS from other psychiatric conditions.

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Last Updated: Jun 16, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

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Published on: August 20, 2019

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Case Study

Background:

  • Kleine-Levin Syndrome (KLS) is a rare disorder with unclear etiopathogenesis.
  • KLS presents with recurrent episodes of hypersomnia, cognitive deficits, and behavioral changes.
  • Accurate diagnosis of KLS is challenging due to its rarity and overlapping symptoms with other psychiatric and neurological conditions.

Observation:

  • A 15-year-old patient experienced KLS symptoms including hypersomnia, confusion, megaphagia, irritability, hypersexuality, and mood disorders after tonsillitis and emotional shock.
  • Symptoms resolved spontaneously within 12 days, with persistent incomplete amnesia.
  • A relapse occurred after alcohol consumption, with no medicinal treatment administered during episodes or asymptomatic periods.

Findings:

  • The case presented no specific psychological profile to support a facilitating psychological hypothesis for KLS.
  • Neuropsychological assessments (WISC-IV, Rey Complex Figure Test, MMPI-A) did not reveal significant abnormalities.
  • Literature review indicates frequent misdiagnosis of KLS as hysteria, schizophrenia, or bipolar disorder, leading to inappropriate treatments.

Implications:

  • This case underscores the importance of clinical recognition of KLS, differentiating it from other disorders.
  • It emphasizes the need for careful consideration of medicinal treatment strategies for KLS.
  • The study suggests KLS should be considered a distinct entity, despite proposed links to bipolar disorders.