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Updated: Jun 16, 2026
Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
Published on: September 12, 2015
[Effect of skeletal muscle contraction on bone capillary permeability: an experimental study in rabbits]
Yu Zhnag1, Dan Jin, Li-chao Wang
1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Objective:
To assess the effect of muscle contraction on bone capillary permeability.
Methods:
Thirty female New Zealand white rabbits were randomly divided into the experimental and control groups (n=15). The bone chambers were implanted medially into the right tibiae of the rabbit, and in the experimental group, the rabbits were stimulated by transcutaneous electrical nerve stimulator (TENS) at 4 Hz (1 h/day, 6 days/week) starting from week 2. From week 3, intravital microscopic observation was carried out weekly till week 10, and the vasculature in the tibiae was observed under fluorescent microscope with FITC and RITC staining. All the images were analyzed by Metamorph program.
Results:
The bone capillary permeability increased significantly in the experimental group.
Conclusion:
Skeletal muscle contraction can increase the capillary permeability.
